Arsenal will play Sporting CP in the Europa League last-16, while Manchester United face Real Betis.
Arsenal reached the last-16 stage by finishing top of Group A ahead of PSV, Bodo/Glimt and FC Zurich.
United, meanwhile, finished behind Real Sociedad in Group E which forced them into a thrilling knockout round play-off against Barcelona.
After a 2-2 draw in the first leg at Camp Nou last week, Erik ten Hag’s side came from behind at Old Trafford to seal a 2-1 win over Barca at Old Trafford on Thursday evening.
Sporting CP will meet Arsenal having comfortably beaten FC Midtjylland 5-1 on aggregate in their knockout round play-off, while Real Betis finished unbeaten and top of Group C ahead of Roma, Ludogorets Razgrad and HJK earlier this season.
EUROPA LEAGUE LAST-16 DRAW IN FULL
Union Berlin vs Union Saint-Gilloise
Sevilla vs Fenerbahce
Juventus vs Freiburg
Bayer Leverkusen vs Ferencvarosi TC
Sporting CP vs Arsenal
Manchester United vs Real Betis
Roma vs Real Sociedad
Shakhtar Donetsk vs Feyenoord
The last-16 ties will be played on the 9th and 16th of March, with the quarter and semi-final draw following the next day.
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